Like many other early public hospitals, the local community initiated the establishment of the Ipswich public hospital through the formation of a Provisional Hospital Committee, elected at a meeting held at the Ipswich court-house in April 1856. This committee wrote to the Colonial Secretary requesting that funding for land, building and furnishing the new hospital at Ipswich be granted. These requests were successful, appearing in the estimates of the Votes and Proceedings of the new Legislative Assembly (NSW). Despite some delays, the new hospital opened in1860, accepting its first patient on the 3rd of March. The Hospital was formally incorporated into the Hospitals Act on the14th of July,1860.
To afford relief to the sick of Ipswich and the surrounding district, and supply, as far as possible, the want of a benevolent institution (Ipswich Hospital Annual Report, 1890). In line with the growth of the population within the city and the surrounding areas, the hospital has continually expanded the range of hospital and medical services provided to meet current needs.
The hospital's board of management was elected annually by the hospital's subscribers, citizens who paid an annual subscription which entitled them the privilege of voting. Elected positions consisted of a president, a treasurer, a committee of twelve, and the honorary medical officers of the hospital. From the elected board members, five members were elected at half-yearly intervals to form an acting-committee, of which the president and treasurer were ex officio members. Colonel Gray was elected as the first president of the Ipswich Hospital Board of Management.
The hospital's voluntary board was reconstituted in May 1936, with control for the institution handed over to a new governmental controlled Ipswich Hospitals District administration, the 'Ipswich Hospitals Board', charged with the maintenance, management and regulation of all hospitals within the district's geographical catchment.
On 1 July 1991, under the "Health Services Act 1991" hospital boards were abolished and administration of the Ipswich Hospital became the responsibility of the West Moreton Regional Health Authority, later the West Moreton Hospital and Health Service.