The Brisbane and South Coast Hospitals Board was constituted under the "Hospitals Act of 1923". The Act establishing the board was assented to on 23 November 1923 and members had to be elected/appointed by 24 May 1924. Areas covered included the cities of Brisbane and South Brisbane; the towns of Coolangatta, Hamilton, Ithaca, Redcliffe, Sandgate, Southport, Toowong, Windsor and Wynnum; the shires of Balmoral, Beenleigh, Belmont, Caboolture, Cleveland, Coomera, Coorparoo, Enoggera, Kedron, Moggill, Nerang, Pine, Sherwood, Stephens, Tambourine, Taringa, Tingalpa, Toombul, Waterford and Yeerongpilly.
An order in council was published on 13 June 1959 stating that the part of the Brisbane and South Coast Hospitals comprising that part of the City of Brisbane south of the Brisbane River, the Shire of Beaudesert and the Shire of Redland shall be excluded from the current district and be constituted as a new district called the "South Brisbane Hospitals Board". The remaining portion of the Brisbane and South Coast Hospitals Board was then renamed as the "North Brisbane Hospitals Board". The board was responsible for the ten hospitals within its geographical boundary.
The Board was charged with the maintenance, management and regulation of all hospitals within its geographical boundary.
The North Brisbane Hospitals Board membership was determined by:
a) the election of 3 members by the contributors to any hospital within the district
b) the appointment of 3 members by the Governor in Council
c) the election of 3 members by the various Local Authorities
Minister for Health and Home Affairs, 6 Jun 1959 - 26 Sep 1963
Minister for Health 26 Sep 1963 - 6 Feb 1986
Minister for Health and Environment 6 Feb 1986 - 9 Dec 1987
Minister for Helath 9 Dec 1987 - 31 Aug 1989
Minister for Health and Attorney-General 31 Aug 1989 - 25 Sept 1989
Minister for Health 25 Sept 1989 -
The "Health Services Act 1991" provided for the dissolution of Hospital Boards and their replacement with Regional Health Authorities. The North Brisbane Hospitals Board was succeeded by the Brisbane North Regional Health Authority on 1 July 1991.