At the recommendation of the Queensland Cancer Committee, on 31 January 1929 the Queensland Cancer Trust was registered as a body corporate by a Letters Patent under the Religious, Educational and Charitable Institutions Act of 1861. At the same time it also became part of the British Empire Cancer Campaign, whose headquarters were in London. An offer was made to the Brisbane and South Coast Hospitals Board to install a deep x-ray treatment plant at the hospital but this was refused. The Sisters of Mercy of the Mater Hospital offered space on their grounds for the new cancer clinic and this was opened on 20 December 1928, and in 1929 the Trust bought half a gram of radium at a cost of 7,000 pounds to commence treatment.
The Queensland Cancer Trust provided treatment free of charge to the public. The Trust also had an extensive education campaign urging early medical attention in order to establish a firm diagnosis and have treatment begin in the early stages of the disease.
When first constituted the Queensland Cancer Trust Committee was comprised of the following representatives:
Co-optative Members: F. Lloyd (chairman), J. Allan, G. Rees (Hon. Treasurer), Hon. T. Beirne, Mrs Cumbrae Stewart
State Government: J. O'Hagan
Queensland University: Dr W. Robertson, J. Henderson
British Medical Association: Dr E. Sandford Jackson, Dr V. McDowall
Australian Workers' Union: W. Riordan
Red Cross Society: W. Robertson
National Council of Women: Mrs Helen Anderson
Country Women's Association: Mrs Kathleen Mylne
The main clinic of the Queensland Cancer Trust was located at the Mater Hospital and this was supported by various regional centers of the Trust which were opened throughout the state. These diagnosis and treatment clinics were based at the Rockhampton, Mackay, Townsville, Cairns, Mossman and Atherton hospitals.
In 1943, Dr. Ralston Paterson, director of the Holt Radium Institute in Manchester, and Dr. Edith Paterson came at the invitation of the Queensland Government to advise on cancer treatment. They recommended that a special institute be established at Brisbane General Hospital where the cancer treatment by radiation for the state would be centralized. It was recommended that the Queensland Cancer Trust should incorporate the treatment section of its organization in the proposed institute, but carry on as a separate body to continue its educational campaign. With the passing of the Amendment to the Health Act 1945, the Queensland Cancer Trust was dissolved. The Queensland Radium Institute was given the responsibility of providing cancer treatment in Queensland and, to assist with this, it was given all of the instruments and equipment of the Queensland Cancer Trust. The Queensland Health Education Council was created to carry on the educational programs previously pursued by the Queensland Cancer Trust and to assist with this it was given control of the Queensland Cancer Trust's financial assets. All members of the Queensland Cancer Trust who were willing were appointed to the new Health Education Council.